Leftover Thanksgiving Ultimate Sandwich

Category: Traditional Thanksgiving Recipes & Holiday Favorites

Transform your holiday leftovers into a crave-worthy sandwich stacked with tender turkey, savory stuffing, tart cranberry sauce, and melty cheese if desired. This classic day-after-Thanksgiving idea keeps the celebration going by blending beloved seasonal flavors between slices of toasted bread. Whether you grill it for crispness or enjoy it cold, it’s a crowd-pleaser for family and friends. Quick to assemble and packed with taste, it’s the perfect way to enjoy comfort food at its best.

Recipes Fives Halima
Created by Mary Loxip Mary Loxip
Last updated on Tue, 25 Nov 2025 14:02:53 GMT
A sandwich with a variety of fillings including turkey, cranberry, and lettuce. Pin
A sandwich with a variety of fillings including turkey, cranberry, and lettuce. | panbite.com

Turning a kitchen full of Thanksgiving leftovers into something craveworthy is pure magic and this ultimate leftover Thanksgiving sandwich is proof I always look forward to the day after the holiday when I can layer turkey cranberry sauce and all the fixings between bread For years assembling these sandwiches with family around the table is as much a tradition as the big meal itself and every bite tastes like a celebration

Every year my kids ask if we can make extra stuffing just so we have plenty for these sandwiches It has become a post Thanksgiving staple in our house and no two sandwiches are ever exactly the same which is part of the fun

Gather Your Ingredients

  • Cooked turkey breast or thigh slices: brings meaty heartiness to the sandwich Opt for moist turkey and slice it thin for even layering
  • Leftover stuffing: adds savory rich flavor and soaks up all the juices Look for stuffing that still has a bit of moisture to keep the sandwich from feeling dry
  • Cranberry sauce: delivers tangy sweetness and a pop of color Use whole berry for texture or smooth sauce for spreadability
  • Sliced cheese like Swiss provolone or sharp white cheddar: brings creaminess and melts beautifully Opt for a cheese that complements other fillings
  • Sturdy sandwich bread: holds everything together without falling apart I like a crusty sourdough or brioche but any favorite loaf works
  • Butter for grilling: creates that irresistible crispy golden outside Choose real butter for the best flavor
  • Mayonnaise or mustard: adds moisture and liftings flavors Spread a thin layer inside if you want extra richness or zing

How to Make It

Choose and prepare your bread:
Select eight hearty slices of sandwich bread Lay them out and spread a thin layer of mayonnaise or mustard on one side of each slice if desired
Layer in the turkey:
Arrange sliced turkey over four bread slices covering them evenly Add as much turkey as you like but do not overload or the sandwich may fall apart
Add the stuffing:
Spoon leftover stuffing atop the turkey pressing gently to form an even layer Use enough to flavor each bite without making the sandwich too thick
Cranberry sauce time:
Spoon cranberry sauce on top of the stuffing Spread gently to cover without squishing layers below Adjust the amount depending on how sweet or tangy you prefer
Add cheese:
If using lay a slice of cheese over the cranberry sauce This step adds creamy meltiness that ties all the flavors together
Close and get ready to grill:
Top each sandwich with a second slice of bread condiment side down Gently press together to hold everything
Grill or toast for crunch:
Optional for a warm crisp sandwich Melt butter in a large skillet over medium heat Place sandwiches in the pan and cook for about three to four minutes per side pressing gently until the bread is golden and the cheese melts
Slice and serve:
Remove from the skillet and transfer to a cutting board Cut sandwiches in half with a sharp knife Enjoy warm while the bread is crisp and flavors meld
A sandwich with lettuce, bacon, and cranberry sauce.
A sandwich with lettuce, bacon, and cranberry sauce. | panbite.com

I adore adding just a little extra cranberry sauce since it brightens up all the savory layers Every sandwich reminds me of sitting at the table with family sharing stories and laughter long after the holiday dinner is done

Flavor Boosters

Packed with flavors from every Thanksgiving dish you love Let cheese come to room temperature for best melt Do not overload the sandwich or the layers may spill out when grilling Leftover components like gravy or roasted vegetables can be tucked into your sandwich for extra flavor

Serving Suggestions

Pair with a simple green salad for a light meal or serve with kettle chips for crunch For a cozy touch serve with a cup of leftover gravy on the side for dipping If you wish add crisp lettuce or leftover veggies for freshness

Creative Twists

Use rotisserie chicken if you are short on turkey Swap in any soft cheese like brie for a decadent twist Brioche or rustic rolls work well if you have no sandwich bread Do not skip the cranberry sauce since its tang cuts through the rich flavors Try experimenting with roasted vegetables or using seasonal breads for extra holiday flair

A sandwich with lettuce, tomato, and bacon.
A sandwich with lettuce, tomato, and bacon. | panbite.com

Enjoy your ultimate Thanksgiving leftover sandwich as a delicious post-holiday treat Make it your own every year and create new family traditions

Common Questions About This Recipe

→ What type of bread works best for this sandwich?

Thick, sturdy breads like sourdough or country loaf hold up well to moist fillings such as turkey, stuffing, and cranberry sauce.

→ Can I add cheese to the sandwich?

Yes, adding a mild cheese such as Swiss or provolone adds delicious creaminess and helps bind the sandwich together.

→ Does the sandwich have to be grilled or toasted?

No, it can be enjoyed cold or at room temperature, but grilling with butter enhances its flavor and creates a crispy texture.

→ Can cranberry sauce be substituted?

If preferred, you can swap cranberry sauce for another chutney or skip it for a more savory take on the sandwich.

→ How can I keep the sandwich from getting soggy?

Spread condiments in a thin layer and use a dense bread to protect the slices from moisture in the fillings.

Leftover Thanksgiving Ultimate Sandwich

Savor autumn flavors with a November sandwich layered with turkey, stuffing, and cranberry sauce. Ideal for post-Thanksgiving gatherings and cozy lunches. Save & click.

Preparation Time
25 minutes
Cooking Time
25 minutes
Complete Time
50 minutes
Created by Mary Loxip: Mary Loxip

Type of Recipe: Thanksgiving

Level of Skill: Perfect for Beginners

Cultural Cuisine: American

Serves: 8 Portion Size (8 grilled sandwiches)

Dietary Needs: ~

What You Need

→ Main Ingredients

01 12 to 16 slices sandwich bread
02 3 cups cooked turkey, sliced or shredded
03 2 cups leftover stuffing
04 1 cup cranberry sauce
05 6 to 8 slices cheddar, Swiss, or provolone cheese (optional)
06 4 tablespoons unsalted butter, softened, for grilling
07 2 tablespoons mayonnaise or mustard, for spreading (optional)

How to Make It

Step 01

Spread a thin layer of mayonnaise or mustard on one side of each slice of sandwich bread, if desired.

Step 02

Arrange turkey evenly over half the bread slices, mayo or mustard side facing up.

Step 03

Spoon stuffing evenly over the turkey slices.

Step 04

Spread cranberry sauce over the stuffing layer.

Step 05

If desired, place a slice of cheese on top of the cranberry sauce on each sandwich.

Step 06

Cover each sandwich with a second slice of bread, condiment side down.

Step 07

Heat a skillet over medium heat. Add butter to the pan and grill sandwiches for 3 to 4 minutes per side, pressing gently, until golden brown and cheese melts.

Step 08

Remove sandwiches from the skillet, slice in half, and serve warm.

Extra Tips

  1. Assembly is easiest with bread sliced at least ½ inch thick; use sturdy sandwich bread to prevent sogginess.

Tools You'll Need

  • Skillet or griddle
  • Spatula
  • Sharp knife

Allergen Information

Always review ingredients for possible allergens and consult a healthcare provider if unsure.
  • Contains wheat, dairy, and egg (if mayonnaise used).

Nutritional Details (Per Serving)

These facts are provided as informational and aren't a substitute for professional advice.
  • Calories: 450
  • Fat Content: 18 grams
  • Carbohydrate Content: 45 grams
  • Protein Content: 15 grams